This virus was first isolated in 1969 from a gray four-eyed opossum (Philander opossum) in Serra do Navio in the Araguari province in Central Brasil. For a long time it was an unassigned virus but in 2005 scientists finally decided to examine it in much greater detail.
Based on the other viruses in the genus Thogotovirus, it is probable that Araguari Virus is being transmitted via ticks. This also means that Araguari Virus is possible much more widespread than one species of opossum.
 Da Silva et al: Araguari virus, a new member of the family Orthomyxoviridae: serologic, ultrastructural, and molecular characterization in American Journal of Tropoical Medicine and Hygiene - 2005